Summary

The SWITCHES database provides stability analysis for about 7.2 million synthetic reaction models, derived from about 35000 distinct reaction topologies. About 10% of these are bistable. Each reaction topology is sampled at least 1000 times to generate distinct models with different rates.

The dataset uses an 'alphabet' of elementary reactions to build up the reaction network. This is biased towards biological reaction systems. The database covers all possible reaction topologies of 3 molecules and up to 6 reactions, and also 4 molecules and 3 reactions.

SWITCHES is subdivided into 6 model categories, according to the number M of molecules and R of reactions, expressed as MxN. Thus a model with 3 molecules and 5 reactions will be in the 3x5 category.

The front page of the SWITCHES database is a clickable tree of all the model topologies in the database.