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Last updated: Aug 12, 2020 |
SWITCHES
Searchable Web Index for Topologies of CHEmical Switches (SWITCHES) a database of biochemical reaction networks that exhibit bistability. The database is curated using the results of the publication "N. Ramakrishnan and U.S. Bhalla, Memory Switches in Chemical Reaction Space", PLoS Computational Biology, Vol. 4, No. 7, July 2008.
Class
The model class is specified by the name: mXn where -m stands for number of molecule, -n stands for number of reaction.
Configuration
The M specifies the configure number of a model, a unique id within each class.
Model
 
For a given configuration there may be many models.
Solution
Here we list the concentrations of the molecules at the solved steady-state.
eigens
This lists the eigenvalues. Depending on the eigens value the solution are classfied as stable, saddle, unstable, line or doublet.
All Models The bar graph displaying the number of configuration for a given class. Click on each bar to view topology for a given class.
Bistable Models The bar graph displaying the number of bistable configuration for a given class. Click on each bar to view topology for a given class.
The Search bar on SWITCHES page
provides access to additional search options. Use of the relevant
options allows to limit your retrieval to a specific subset of data
within SWITCHES.
Signature
- The search string should start and end with delimiter vertical bars '|', the first letter of the
signature specifies the reaction from the signature list below, and the following lower case letters
identify the molecules. X indicates that the reaction only involves two molecules so there is
no third entry.
The signature list AabX, BabX, CabX, DabX, Eabc, Fabc, Gabc, Habc, Iabc, Jabc, Kabc, Labc
- One can add multipy such signature by vertical bar '|' as delimiter. E.g |Fabc|CabX|.
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Any
Default SWITCHES search looks for the query
term anywhere in the string. When the Any is
selected from the radio button menu or when default searches are run,
SWITCHES is queried for any form of
occurrence of the query term. E.g. When SWITCHES is searched for
CabX the actual search is done for wild card
CabX wild card and this will
yield |AabX|CabX|,
CabX and |CabX|Dbca|EbcX| in the
search results.
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Exact
When the Match field
parameter Exact is selected from the radio button menu
and the searches are run, SWITCHES is queried for the occurrence of
the exact query term. E.g. When an Exact search is
executed for CabX, the actual search is done exactly for CabX
and this will yield only |CabX| in the search results and not
|AcaX|CabX|
or |CabX|Labc|.
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SWITCHES Team
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